![]() Multiple Myeloma Mnemonic: Diagnostic Test for Multiple Myeloma: Renal failure and infection are the most common causes of death in multiple myeloma.Neurological symptoms: Common problems are weakness, confusion and fatigue due to hypercalcemia. Headache, visual changes and retinopathy may be the result of hyperviscosity of the blood depending on the properties of the paraprotein.Constipation: is due to electrolyte disturbances such as hypercalcemia.Although the total immunoglobulin level is typically elevated in multiple myeloma, but these immunoglobulins are useless and are not able to fight the infections. Infection: This is due to immune deficiency.Increased bone resorption leads to hypercalcemia and causes nephrocalcinosis thereby contributing to the renal failure. Renal failure: The most common cause of renal failure in multiple myeloma is due to tubulopathic effects of the light chains (Bence Jones proteins).Anemia: It results from the replacement of normal bone marrow by infiltrating tumor cells and inhibition of normal red blood cell production.The bone pain is due to pathologic fracture which a fracture of a bone under what we would consider normal use. Most commonly back pain and rib pain since the osteoclast activating factors area causing bone lysis. Bone pain: This is the most common presentation of multiple myeloma.These antibodies are IgG or IgA which do not fight infections but clog up the kidney. In multiple myeloma, these plasma cells are unregulated in their production and therefore they make useless antibodies. Normal plasma cells are responsible for making antibodies that helps the body fight infections. Multiple myeloma (aka Plasma cell myeloma), is an abnormal proliferation of plasma cells, a type of white blood cell present in the bone marrow. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
December 2022
Categories |